Board-certified dermatologists Dr. Ronald C. Knipe and Dr. Samantha A. Marrone, together with our dermatology-certified nurse practitioners and physician assistant, have cared for patients in greater Orlando for more than 25 years.
Downtown Dermatology specializes in dermatological surgery and the treatment of general dermatological skin conditions. Our board-certified physicians and licensed providers care for patients across every age and every concern — from pediatric rashes and teenage acne to adult skin cancer screenings and cosmetic rejuvenation.
We practice traditional medical dermatology with a modern standard of care: unhurried appointments, direct physician involvement, and attention to detail.
Three integrated service lines, all delivered in-office by board-certified physicians and licensed providers.
Comprehensive diagnosis and treatment for common and complex skin conditions, from infants to seniors.
Minimally invasive removal of growths and suspicious lesions, performed by our board-certified physicians.
Evidence-based cosmetic dermatology — natural, refined results administered by experienced physicians.
Two physicians, two advanced-practice registered nurses, and a physician assistant — caring for Central Florida skin together.

Dr. Knipe has practiced dermatology in Orlando for more than 25 years, providing medical, surgical, and cosmetic care with a focus on skin cancer detection and minor surgical procedures.

Dr. Marrone partners with Dr. Knipe to care for patients across every dermatologic need — medical, surgical, and cosmetic — with a warm, detailed, patient-first approach.
@samtheskindoc →
Dermatology-certified nurse practitioner working alongside the physicians across the full range of medical dermatology care.

Dermatology-certified nurse practitioner providing comprehensive medical and cosmetic dermatology care.
@jenthedermnp →
Physician assistant specializing in dermatology, partnering with the practice's physicians to deliver thorough, attentive patient care.
From the front desk to the treatment room, our staff is the reason patients have stayed with us for decades. Bilingual English and Spanish service. Trained. Personable. Long-tenured.
We're a private, independent practice. You see a physician. You're not rushed. And your chart doesn't get lost in a corporate system.
Direct involvement from Dr. Knipe and Dr. Marrone on every case.
Medical, surgical, and cosmetic — all performed in-office.
Most major insurance plans accepted for covered medical visits.
Central Orlando location with parking. Bilingual EN / ES staff.
Please call the office to verify your specific plan and coverage. Cosmetic services are typically not insurance-covered.









Additional plans accepted including Allegiant, Assurant, GEHA, Golden Rule, Great West / Cigna, Cigna Healthspring, and VA. Call (407) 581-2888 to verify yours.
Patients have been coming here for 10, 15, even 20+ years. Many were referred by family members and friends.
Read patient reviews →Central downtown location, just south of Orlando Health and Lake Lucerne.
70 W Gore Street, Suite 200A
Orlando, FL 32806
Call our office to book with Dr. Knipe, Dr. Marrone, or one of our advanced-practice providers.